Synthesis and in vitro α-glucosidase inhibitory activity of some of the derivatives of 3-methylrhodanine

In the further research and synthesis of highly bioactive 3-methylrhodanine derivatives, preparation benzylidene rhodanines followed by bicyclization to form pyrazole compounds has been undertaken. Using a convenient simple method, twelve have synthesized including six rhodanine derivatives ranging from good excellent yield, with four phenylhydrazone two at low yield. The structures all were elucidated spectral methods analysis. Among them, heterocyclic compounds, namely 4-(2-phenylhydrazono)-5-benzylidene-3-methylthiazolidine-2-thione (3'a-3'd), 3-(4-nitrophenyl)-2-phenyl-2,6-dihydro-5H-pyrazolo[3,4-d]thiazole-5-thione (3''e), 3-(4-cyanophenyl)-2-phenyl-2,6-dihydro-5H-pyrazolo[3,4-d]thiazole-5-thione (3''f) for first time. evaluated in vitro against α-glucosidase exhibited promising antidiabetic activity IC50 values 11.3 21.9 µM.